This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Majocha, R. E. Articles by Marotta, C. A. Search for Related Content PubMed Articles by Majocha, R. E. Articles by Marotta, C. A. Social Bookmarking                   What's this?

Molecular and Genetic Investigations on Alzheimer Brain Amyloid

Department of Psychiatry and Program in Neuro-science, Harvard Medical School, Boston, MA, Neurobiology Laboratory, Psychiatry Service, Massachusetts General Hospital, Boston, MA, Mailman Research Center, McLean Hospital, Belmont, MA.

Charles A. Marotta, MD, PhD

Department of Psychiatry and Program in Neuro-science, Harvard Medical School, Boston, MA, Neurobiology Laboratory, Psychiatry Service, Massachusetts General Hospital, Boston, MA, Mailman Research Center, McLean Hospital, Belmont, MA.

Amyloid-containing plaques are a characteristic feature of the Alzheimer's disease brain and have been the object of study for decades. Only recently, however, have molecular and genetic techniques been applied to examination of amyloid in order to understand the factors that contribute to the accumulation of plaques in dementia. Current investigations have focused on the structure and properties of the amyloid protein, its corresponding messenger RNA, its cellular site of pro duction, and its chromosomal site of origin. These data are discussed in the present review. (J Geriatr Psychiatry Neurol 1988;1:65-70).

Journal of Geriatric Psychiatry and Neurology, Vol. 1, No. 2, 65-70 (1988)
DOI: 10.1177/089198878800100202


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?