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Journal of Geriatric Psychiatry and Neurology, Vol. 1, No. 4, 212-217 (1988)
DOI: 10.1177/089198878800100405
© 1988 SAGE Publications

Identifying Persistent Adverse Effects of Anticholinergic Drugs in the Elderly

Ira R. Katz

Philadelphia Geriatric Center and the Medical College of Pennsylvania, Philadelphia, PA

David Stoff

Philadelphia Geriatric Center and the Medical College of Pennsylvania, Philadelphia, PA

Cathy Muhly

Philadelphia Geriatric Center and the Medical College of Pennsylvania, Philadelphia, PA

Merle Bari

Philadelphia Geriatric Center and the Medical College of Pennsylvania, Philadelphia, PA

Investigations on the symptoms associated with the use of anticholinergic medications by elderly patients demonstrated that these medications are frequently associated with persistent adverse effects that may go unrecognized by both patients and physicians. An increase in autonomic symptoms was readily demonstrated in a group of elderly outpatients taking anti cholinergics. Cognitive effects, however, were not apparent, possibly due to the heterogeneity of the populations studied. A parallel study did, however, demonstrate an association between anticholinergic medications and slowing of EEG back ground frequency. Findings on the relationship between EEG background frequency and cognitive measures suggest the possible value of the combined use of psychological and electrophysiological measures for identifying patients who require further evaluation of their medication regimen. (J Geriatr Psychiatry Neurol 1988;1:212-217).


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