This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Marar, I. E. Articles by Amico, J. A. Search for Related Content PubMed PubMed Citation Articles by Marar, I. E. Articles by Amico, J. A. Social Bookmarking                         What's this?

Effect of Paroxetine on Plasma Vasopressin and Water Load Testing in Elderly Individuals

Adele L. Towers, MD

Benoit H. Mulsant, MD

Bruce G. Pollock, MD, PhD

Janet A. Amico, MD

Hyponatremia sometimes occurs in elderly depressed patients treated wtih a serotonin reuptake inhibitor (SRI). The cause of the hyponatremia is not yet understood. The objective of this study was to determine the effects of paroxetine, an SRI, on osmoregulated release of vasopressin (also termed antidiuretic hormone) in elderly depressed patients with normal serum sodium. Four women and one man ages 61 to 74 years with a major depressive disorder were administered a water load after they had been treated with a therapeutic dose of paroxetine for 3 to 11 months. Three healthy elderly subjects not receiving paroxetine served as controls. Both the patients and the control subjects excreted > 90% of the ingested water and lowered urine osmolality to < 100 mosmol/kg. We conclude that long-term treatment with paroxetine alone does not appear to affect the ability to excrete a water load or appropriately dilute the urine during a water load (both indices of vasopressin function) in a small group of elderly patients without other risk factors for the development of hyponatremia. (J Geriatr Psychiatry Neurol 2000; 13:212-216).

Journal of Geriatric Psychiatry and Neurology, Vol. 13, No. 4, 212-216 (2000)
DOI: 10.1177/089198870001300407


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?