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Journal of Geriatric Psychiatry and Neurology, Vol. 15, No. 1, 50-54 (2002)
DOI: 10.1177/089198870201500110
© 2002 SAGE Publications

The Global Deterioration Scale: Relationships to Neuropsychological Performance and Activities of Daily Living in Patients with Vascular Dementia

Robert H. Paul, PhD

Department of Psychiatry and Human Behavior

Ronald A. Cohen, PhD

Department of Psychiatry and Human Behavior

David J. Moser, PhD

Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa

Tricia Zawacki, PhD

Department of Psychiatry and Human Behavior

Brian R. Ott, MD

Department of Clinical Neurosciences, Brown University School of Medicine, Miriam Hospital, Providence, Rhode Island

Norman Gordon, MD

Department of Clinical Neurosciences, Brown University School of Medicine, Miriam Hospital, Providence, Rhode Island

William Stone, MD

Department of Clinical Neurosciences, Brown University School of Medicine, Miriam Hospital, Providence, Rhode Island

In the present study, we examined the relationships between ratings on the Global Deterioration Scale (GDS) and activities of daily living and cognitive function in 39 individuals with vascular dementia (VaD). The results of the study revealed significant correlations between GDS rating and performance on cognitive tests, including memory and overall cognitive ability. In addition, the GDS was significantly related to ratings of instrumental activities of daily living. Comparisons between patients with VaD with GDS scores between 4 and 6 (n = 21) and patients with scores between 2 and 3 (n = 18) revealed greater cognitive and functional deficits in the group with higher GDS scores. Further, the GDS score accurately classified 87% of the patients with VaD. These findings provide support for the validity of the GDS in general staging of dementia severity of VaD. (J Geriatr Psychiatry Neurol 2002; 15:50-54).


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