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Decline in Long-Term Circadian Rest-Activity Cycle Organization in a Patient with Dementia

Centre for Chronobiology and Alzheimer's Research Group, Psychiatric University Clinic Basel, Basel, Switzerland

Egemen Savaskan, MD

Vera Knoblauch, MSc

Centre for Chronobiology and Alzheimer's Research Group, Psychiatric University Clinic Basel, Basel, Switzerland

Paola Fontana Gasio, MA

Centre for Chronobiology and Alzheimer's Research Group, Psychiatric University Clinic Basel, Basel, Switzerland

Eus J. W. Van Someren, PhD

Netherlands Institute for Brain Research, Amsterdam, The Netherlands

Christoph Hock, MD

Centre for Chronobiology and Alzheimer's Research Group, Psychiatric University Clinic Basel, Basel, Switzerland

Anna Wirz-Justice, PhD

Centre for Chronobiology and Alzheimer's Research Group, Psychiatric University Clinic Basel, Basel, Switzerland

Continuous measurement of the circadian rest-activity cycle for 598 days in a demented patient with probable Alzheimer's disease revealed slow progressive changes in temporal organization until death. Circadian and sleep analysis of the actigraphic data provided objective documentation of the gradual insertion of wakefulness into rest and rest into wake periods. Pacing, a nonphotic zeitgeber strengthening, led to improved synchronization of the rest-activity cycle. (J Geriatr Psychiatry Neurol 2002; 15:55-59).

Journal of Geriatric Psychiatry and Neurology, Vol. 15, No. 1, 55-59 (2002)
DOI: 10.1177/089198870201500111


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