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•1-Acid Glycoprotein in Late-Life Depression: Relationship to Medical Burden and Genetics

University of Pittsburgh, Pittsburgh, Pennsylvania Department of Emergency Medicine, University of Cincinnati, Cincinnati, Ohio

Robert E. Ferrell, PhD

University of Pittsburgh, Pittsburgh, Pennsylvania Department of Human Genetics, Graduate School of Public Health

Margaret A. Kirshner, BA

University of Pittsburgh, Pittsburgh, Pennsylvania Department of Psychiatry

Benoit H. Mulsant, MD

University of Pittsburgh, Pittsburgh, Pennsylvania, the Geriatric Research Education and Clinical Center,VA Pittsburgh Health Care System, Pittsburgh, Pennsylvania

Karen Seligman, MEd

University of Pittsburgh, Pittsburgh, Pennsylvania Department of Psychiatry

Amy E. Begley, MA

University of Pittsburgh, Pittsburgh, Pennsylvania Department of Psychiatry

Charles F. Reynolds, III, MD

University of Pittsburgh, Pittsburgh, Pennsylvania Department of Psychiatry

Bruce G. Pollock, MD, PhD

University of Pittsburgh, Pittsburgh, Pennsylvania Department of Psychiatrypollockbg{at}upmc.edu

Serum •1-acid glycoprotein (AAG) concentrations were examined in relationship to age, medical burden, depression, and mental status in elderly control (n = 19, mean age = 72.1 ± 6.8 years) and depressed (n = 58, mean age = 71.9 ± 7.1 years) subjects. DNA was analyzed for allelic variants of the AGP1 (ORM1) gene in both groups. Depressed subjects’ AAG serum levels were measured at baseline and after 6 weeks of antidepressant treatment. Before treatment, depressed subjects had significantly higher serum AAG concentrations than nondepressed controls (t49.2 = –3.48, P= .0011). Pretreatment AAG levels also correlated with degree of medical burden, measured by the Cumulative Illness Rating Scale–Geriatrics (r= 0.28, P= .0303), but not with age, depression severity, or cognitive scores. There was no significant difference between responders and nonresponders on changes in AAG levels from baseline to week 6. Frequency differences in ORM1 allelic variants apparently did not influence increased AAG concentrations in depressed patients.

Key Words: •1-acid glycoprotein • AAG • late-life depression • CIRS-G

Journal of Geriatric Psychiatry and Neurology, Vol. 16, No. 4, 235-239 (2003)
DOI: 10.1177/0891988703258321


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