Journal of Geriatric Psychiatry and Neurology

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Free Access - Register Here

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yesavage, J. A.
Right arrow Articles by Murphy, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yesavage, J. A.
Right arrow Articles by Murphy, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Geriatric Psychiatry and Neurology, Vol. 17, No. 1, 20-24 (2004)
DOI: 10.1177/0891988703261994

Sleep/Wake Disruption in Alzheimer’s Disease: APOE Status and Longitudinal Course

Jerome A. Yesavage, MD

National Institute of Aging Alzheimer’s Disease Core Center, Palo Alto VA Health Care System (151Y), 3801 Miranda Avenue, Palo Alto, CA 94304yesavage{at}stanford.edu

Leah Friedman, PhD

Helena Kraemer, PhD

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California

Jared R. Tinklenberg, MD

Palo Alto Veterans Affairs Health Care System, Palo Alto, California; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California

Ahmad Salehi, MD

Art Noda, MS

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California

Joy L. Taylor, PhD

Palo Alto Veterans Affairs Health Care System, Palo Alto, California; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California

Ruth O’Hara, PhD

Greer Murphy, MD, PhD

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California

Disturbed sleep is a major clinical problem in Alzheimer’s disease (AD). Apolipoprotein •4 (APOE •4) carrier status may increase risk of AD, yet there are no data on relations between APOE status and progression of sleep disturbance in AD. The objective of this study was to determine if sleep parameters in AD patients change over time as a function of APOE carrier status. Forty-four community-dwelling AD patients with diagnosis of probable AD were followed from early stages of disease. Their sleep/wake parameters were compared according to APOE status. For APOE •4 carriers, only wake after sleep onset (WASO) increased in association with lower cognitive function as indicated by the Mini-Mental State Examination (MMSE); for non-•4 subjects, increases in WASO and declines in total sleep time, sleep efficiency, and the amplitude of the rest/activity circadian rhythm over time were associated with lower performance on the MMSE. In these data, APOE status was associated with the progression of sleep/wake disturbances in AD. Overall, there was greater deterioration on sleep parameters in patients negative for the •4 allele.

Key Words: Alzheimer’s disease • dementia severity • longitudinal studies • sleep/wake disturbances • circadian rhythm • apolipoprotein •


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?