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Neuropsychosocial Features of Very Mild Alzheimer’s Disease (CDR 0.5) and Progression to Dementia in a Community: The Tajiri Project

Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine; Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai, 9808575, Japan; k-meg{at}umin.ac.jp

Masumi Shimada, PhD

Satoshi Yamaguchi, MD, PhD

Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine

Iwao Sano, MD

Department of Psychiatry, University of Tokyo

Hiroki Inagaki, MSc

Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine

Masaaki Matsushita, MD, PhD

Department of Psychiatry, University of Tokyo

Yasuyoshi Sekita, PhD

Division of Health Care System Science, Tohoku University Graduate School of Economics

Etsuro Mori, MD, PhD

Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine

The borderline condition between normal aging and dementia should be detected to predict further deterioration. The authors cross-sectionally analyzed neuropsychological data, memory complaints, and social activities for communitydwelling older adults. The rate of decline from Clinical Dementia Rating (CDR) 0.5 to dementia during a 3-year interval was also analyzed. Short-term memory rather than long-term memory was found to be sensitive in distinguishing those with CDR 0 from those with CDR 0.5. Relatives’ observations of memory decline rather than subjective memory complaints were significantly different. Participants with CDR 0.5 reported fewer problems with social activities than did their relatives. Ten of the 29 CDR 0.5 participants (34.5%) showed cognitive decline, the decliners showing lower scores on short-term memory and orientation at the baseline condition. The neuropsychological data showed CDR 0.5 to be similar to very mild Alzheimer’s disease. It would be better if subjective complaints were excluded from the criteria of the borderline condition.

Key Words: Alzheimer’s disease • Clinical Dementia Rating 0.5 • Cognitive Abilities Screening Instrument • communitybased study

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