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Serum Levels of Soluble Intercellular Adhesion Molecule-1 and Soluble Endothelial Leukocyte Adhesion Molecule-1 in Alzheimer’s Disease

Department of Neurology, Aeginition Hospital, Athens Medical School, Vass. Sophias av. 72-74, 11528 Athens, Greece, mrentzos{at}med.uoa.gr,mrentzos@in.gr

M. Michalopoulou, MD

C. Nikolaou, MD

C. Cambouri, MD

Biopathology-Neuroimmunology, Aeginition Hospital, Athens Medical School, Greece.

A. Rombos, MD

A. Dimitrakopoulos, MD

E. Kapaki, MD

D. Vassilopoulos, PhD

Department of Neurology Aeginition Hospital, Athens Medical School, Greece.

Serum soluble intercellular adhesion molecule-1 (s-ICAM-1) and soluble E-selectin (s-ELAM-1) were evaluated in 25 patients with Alzheimer’s disease (AD), 54 patients with noninflammatory neurological diseases (NIND), and 15 control subjects. Patients with AD had a higher s-ICAM-1 level compared with the NIND patients and the control subjects (P< .001 and P< .04, respectively). The presence of high s-ICAM-1 values may be related to immunological processes involved in pathogenetic mechanisms of AD. The not statistically significant values of (s-ELAM-1), a glycoprotein considered an exclusive marker of endothelial activation, compared with the NIND patients and healthy subjects (P< .47 and P< .17, respectively), seem to suggest the neural rather than the endothelial s-ICAM origin in patients with AD.

Key Words: ICAM-1 • ELAM-1 • Alzheimer’s disease • immunological processes

Journal of Geriatric Psychiatry and Neurology, Vol. 17, No. 4, 225-231 (2004)
DOI: 10.1177/0891988704269822


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