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Journal of Geriatric Psychiatry and Neurology, Vol. 18, No. 3, 163-173 (2005)
DOI: 10.1177/0891988705277549
© 2005 SAGE Publications

The Diagnostic Value of Cerebrospinal Fluid Tau Protein in Dementing and Nondementing Neuropsychiatric Disorders

George P. Paraskevas, MD

Department of Neurology, School of Medicine, Athens National University, Eginition Hospital, 74 Vas. Sophias Ave, Athens 11528, Greece

Elisabeth Kapaki, MD

Department of Neurology, School of Medicine, Athens National University, Eginition Hospital, 74 Vas. Sophias Ave, Athens 11528, Greece, ekapaki{at}med.uoa.gr

Ioannis Liappas, MD

Department of Psychiatry, School of Medicine, Athens National University, Eginition Hospital, 74 Vas. Sophias Ave, Athens 11528, Greece

Ioulia Theotoka, MSc

Department of Psychiatry, School of Medicine, Athens National University, Eginition Hospital, 74 Vas. Sophias Ave, Athens 11528, Greece

Ioanna Mamali

Department of Neurology, School of Medicine, Athens National University, Eginition Hospital, 74 Vas. Sophias Ave, Athens 11528, Greece

Christos Zournas, MD

Department of Neurology, School of Medicine, Athens National University, Eginition Hospital, 74 Vas. Sophias Ave, Athens 11528, Greece

Lefteris Lykouras, MD, PhD

Department of Psychiatry, School of Medicine, Athens National University, Eginition Hospital, 74 Vas. Sophias Ave, Athens 11528, Greece, Department of General Hospital Psychiatry, Attikon Hospital, Athens, Greece

Cerebrospinal fluid (CSF) total tau protein ({tau}T) is increased in Alzheimer’s disease (AD) and may be of some help in the diagnostic work-up of demented patients. The aim of the present study was to investigate the diagnostic aid and the additional help (over that of clinical criteria) of {tau}T in different clinical situations. Double-sandwich enzyme-linked immunosorbent assay was used to quantify {tau}T in 61 healthy controls and 241 patients with various neuropsychiatric diseases. Our results suggest that CSF {tau}T offers significant additional information over that of clinical criteria of AD, for the discrimination of AD from normal aging, depression, synucleinopathy, and possibly vascular dementia. However, for the differential diagnosis from frontotemporal dementia, corticobasal ganglionic degeneration, and secondary dementia, the diagnostic value is inadequate.

Key Words: Alzheimer’s disease • Parkinson’s disease • dementia • cerebrospinal fluid • tau protein


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