Journal of Geriatric Psychiatry and Neurology

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

SAGETRACK

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Swan, G. E.
Right arrow Articles by La Rue, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Swan, G. E.
Right arrow Articles by La Rue, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Geriatric Psychiatry and Neurology, Vol. 18, No. 4, 196-201 (2005)
DOI: 10.1177/0891988705281864

Apolipoprotein E {epsilon}4 and Change in Cognitive Functioning in Community-Dwelling Older Adults

Gary E. Swan, PhD

Center for Health Sciences, SRI International, Menlo Park, California, gary.swan{at}sri.com

Christina N. Lessov-Schlaggar, PhD

Center for Health Sciences, SRI International, Menlo Park, California

Dorit Carmelli, PhD

Center for Health Sciences, SRI International, Menlo Park, California

Gerard D. Schellenberg, PhD

Geriatric Research, Education, and Clinical Center, University of Washington, Seattle

Asenath La Rue, PhD

Wisconsin Alzheimer’s Institute, University of Wisconsin, Madison

The relationship between apolipoprotein E (APOE) {epsilon}4 and change in cognition was examined in older men (n = 247; age = 75.0 ± 3.5 years) and women (n = 79; age = 70.8 ± 4.9 years) free of history of stroke. Participants were examined again 4.0 ± 0.5 years later. Exclusion criteria were (1) initial scores on the Mini-Mental State Examination of 23 or less or (2) the presence of the APOE 2/4genotype. Men with {epsilon}4showed greater decline in some measures of executive function and verbal memory compared to those without {epsilon}4; women with {epsilon}4showed greater decline in Trail Making test performance relative to women without the allele. A significant gender x APOE{epsilon}4interaction was seen for change in performance on short delay cued recall. These results suggest that APOE{epsilon}4is associated with cognitive decline differently in older adult men and women.

Key Words: cognitive decline • elderly • gender difference • APOE {epsilon}4


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J Geriatr Psychiatry NeurolHome page
L. F. Jarvik and D. Blazer
Children of Alzheimer Patients: An Overview
J Geriatr Psychiatry Neurol, December 1, 2005; 18(4): 181 - 186.
[PDF]