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Performance on Neurocognitive Tests by Co-twins to Dementia Cases Compared to Normal Control TwinsDepartment of Psychology, University of Southern California, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, gatz{at}usc.edu
Department of Psychology, University of Southern California
Department of Psychology, University of California, Riverside
Department of Psychology, Göteborg University
Aging Research Center, Karolinska Institutet
Department of Psychology, University of Southern California, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet Nondemented co-twins of twins who were diagnosed as demented were compared to randomly selected members of normal control twin pairs in which both members of the pair were nondemented. Nondemented co-twins included 23 monozygotic and 62 dizygotic twins; there were 27 normal control twins. Both monozygotic and dizygotic nondemented co-twins of dementia cases scored significantly lower than normal control twins on 5 of 10 cognitive tests. Moreover, monozygotic co-twins of dementia cases had a generally lower score profile than dizygotic co-twins of dementia cases did. These findings show that being at greater genetic risk for dementia is reflected in cognitive performance even in the absence of a diagnosis of dementia.
Key Words: twins • dementia • Alzheimer’s disease • neuropsychological tests • elderly
Journal of Geriatric Psychiatry and Neurology, Vol. 18, No. 4,
202-207 (2005) This article has been cited by other articles:
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