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Journal of Geriatric Psychiatry and Neurology
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Selected Topics in Statistical Analysis of Clinical Research

Lee Baer

Departments of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA

David K. Ahern

Institute for Behavioral Medicine and the Department of Psychiatry and Human Behavior, Brown University Program in Medicine, Providence, RI

Statistical analysis usually is employed in the evaluation of clinical research studies. This paper reviews and makes recom mendations in three areas frequently overlooked in the conduct of clinical research: power analysis, specification of a priori research hypotheses, and Bayesian analysis. Power analysis determines the number of subjects required to conduct a mean ingful study and should be performed during the planning phase. Research and null hypotheses are essential elements of research design and should be specified prior to statistical analysis. Bayesian analysis can be used both to evaluate diag nostic tests and as an alternative to traditional statistical approaches for testing multiple hypotheses. Application of these methods is described and clinical examples are provided. The discussion is nontechnical and is directed toward the clinical researcher. (J Geriatr Psychiatry Neurol 1989;2:34-40).

Journal of Geriatric Psychiatry and Neurology, Vol. 2, No. 1, 34-40 (1989)
DOI: 10.1177/089198878900200107
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