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Journal of Geriatric Psychiatry and Neurology, Vol. 2, No. 2, 70-75 (1989)
DOI: 10.1177/089198878900200203

HLA Antigens in Depressed, Demented, and Nondemented Elderly

Gary W. Small

Department of Psychiatry and Biobehavioral Sciences, UCLA Neuropsychiatric Institute, and the West Los Angeles Veterans Administration Medical Center, Brentwood Division, Los Angeles, CA

Steven S. Matsuyama

Department of Psychiatry and Biobehavioral Sciences, UCLA Neuropsychiatric Institute, and the West Los Angeles Veterans Administration Medical Center, Brentwood Division, Los Angeles, CA

Ramanujam Komanduri

Department of Psychiatry and Biobehavioral Sciences, UCLA Neuropsychiatric Institute, and the West Los Angeles Veterans Administration Medical Center, Brentwood Division, Los Angeles, CA

James E. Spar

Department of Psychiatry and Biobehavioral Sciences, UCLA Neuropsychiatric Institute, West Los Angeles Veterans Administration Medical Center, Brentwood Division, Los Angeles, CA

Lynn Fairbanks

Department of Psychiatry and Biobehavioral Sciences, UCLA Neuropsychiatric Institute, West Los Angeles Veterans Administration Medical Center, Brentwood Division, Los Angeles, CA

To identify HLA antigen associations with geriatric depression, the authors typed 36 elderly patients with major depression and, for comparison, 36 patients with Alzheimer-type dementia and 29 nondemented elderly controls. The frequency for antigen Aw32 was significantly higher in the group of patients with major depression (14%) than in the demented (0%) and control (3%) groups. The frequencies for antigens Aw32 (22%) and Bw51 (22%) were significantly higher in the subgroup of 23 patients with endogenous depression than in the demented (Aw32 = 0%; Bw51 = 11%) and the control (Aw32 = 3%; Bw51 = 0%) groups. Although these results were derived from a relatively small sample (n = 101) and become nonsignificant when corrected for multiple comparisons, they suggest that HLA antigen associations may be present for only certain depressive subtypes in geriatric depression. (J Geriatr Psychiatry Neurol 1989;2:70-75).


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