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Early-Onset Alzheimers Disease Is Associated With Greater Pathologic BurdenDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, gamarchall{at}partners.org
Psychiatry and Biobehavioral Neuroscience, David Geffen School of Medicine, University of California, Los Angeles
Florham Park, New Jersey
Department of Neurology, Pathology and Laboratory Medicine, Neuropathology, David Geffen School of Medicine, University of California, Los Angeles
Department of Neurology, Psychiatry and Biobehavioral Neuroscience, David Geffen School of Medicine, University of California, Los Angeles Two subtypes of Alzheimers disease (AD) have been commonly identified: early- and late-onset forms. Previous studies suggest that early-onset AD patients have more neuritic plaques (NPs) and neurofibrillary tangles (NFTs). In the current study, NP and NFT counts were performed for 8 brain regions in 25 subjects with definite AD. A repeated-measures analysis of variance of mean regional NP and NFT counts for early- and late-onset groups was performed. A significant between-subject effect indicating greater overall NP and NFT burden in the early-onset group was observed (NP: F = 6.8, df = 1, P = .015; NFT: F = 7.5, df = 1, P = .012). This analysis supports the hypothesis that early-onset AD is associated with greater pathologic burden than late-onset AD. This suggests that late-onset AD patients have less cognitive reserve than early-onset patients and require fewer pathologic changes to exhibit cognitive deterioration.
Key Words: Alzheimers disease early onset late onset pathology neuritic plaques neurofibrillary tangles
Journal of Geriatric Psychiatry and Neurology, Vol. 20, No. 1,
29-33 (2007) This article has been cited by other articles:
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