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Conversion to Dementia From Questionable Dementia in an Ethnic Chinese Population

Department of Neurology, National Yang-Ming University School of Medicine, Taipei, hcliu{at}vghtpe.gov.tw, Neurological Institute, Taipei Veterans General Hospital, Taipei

Pei-Ning Wang, MD

Department of Neurology, National Yang-Ming University School of Medicine, Taipei, Neurological Institute, Taipei Veterans General Hospital, Taipei

Hsiao-Chien Wang, MS

Neurological Institute, Taipei Veterans General Hospital, Taipei

Ker-Neng Lin, PhD

Neurological Institute, Taipei Veterans General Hospital, Taipei, Department of Psychology, Fu Jen Catholic University, Taipei, Taiwan

Chen-Jee Hong, MD

Department of Psychiatry (Dr Hong), National Yang-Ming University School of Medicine, Taipei, Department of Psychiatry (Dr Hong), Taipei Veterans General Hospital, Taipei

Chia-Yih Liu, MD

Department of Psychiatry, Chang Gung University School of Medicine and Chang-Gung Memorial Hospital, Taoyuan

Ping-Huang Tsai, MD

Department of Neurology, National Yang-Ming University School of Medicine, Taipei, Neurological Institute, Taipei Veterans General Hospital, Taipei

We investigated the conversion rate and the risk factors for conversion to dementia from questionable dementia in 124 ethnic Chinese subjects with questionable dementia at a memory clinic of a university hospital. They were evaluated annually based on cognitive testing, the clinical dementia rating scale, and a psychiatrist's interview for depression and anxiety. Apolipoprotein E genotyping was performed on 111 of these questionable dementia subjects. All subjects were evaluated at least twice during the follow-up period of 20.4 ± 12.4 months. During that period, 42 questionable dementia subjects were diagnosed as having Alzheimer's disease, with an annual conversion rate to dementia of 19.9%. Compared with the 82 nonconverters, the 42 converters were significantly older, had lower cognitive, depression, and anxiety scores, and a higher frequency of the apolipoprotein E 4 allele. Cox regression analysis revealed that the Alzheimer's disease converters had lower scores for orientation, short-term memory, and anxiety, and a higher frequency of the apolipoprotein E 4 allele than the nonconverters. (J Geriatr Psychiatry Neurol 2007;20:76-83)

Key Words: Alzheimer's disease • questionable dementia • cognitive abilities screening instrument

Journal of Geriatric Psychiatry and Neurology, Vol. 20, No. 2, 76-83 (2007)
DOI: 10.1177/0891988706298626


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