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FMR1 Alleles in Parkinson's Disease: Relation to Cognitive Decline and Hallucinations, A Longitudinal Study

Department of Neurology, Heinrich-Heine-University, Düsseldorf, Germany, kurzmartin{at}gmx.net, Department of Neurology, Stavanger University-Hospital, Stavanger, Norway

Anna Melissa Schlitter

Department of Human Genetics, Ruhr-University, Bochum, Germany

Yvonne Klenk

Department of Human Genetics, Ruhr-University, Bochum, Germany

Thomas Mueller, MD

Jan Petter Larsen, MD, PhD

Department of Neurology, Stavanger University-Hospital, Stavanger, Norway

Dag Aarsland, MD, PhD

Psychiatric Clinic, Stavanger University-Hospital, Stavanger, Norway

Gabriele Dekomien, PhD

Department of Human Genetics, Ruhr-University, Bochum, Germany

Carriers of expanded alleles of the fragile X mental retardation (FMR1) gene may display parkinsonism, cognitive decline, and behavioral changes. The authors screened 2 male groups of patients affected with Parkinson's disease (PD) (n = 137). One group (n = 56) was followed longitudinally for up to 12 years. Length of CGG repeats in PD patients was compared with healthy controls (n = 310). In addition, the association of the number of CGG repeats with cognitive decline or hallucinations was studied in the longitudinally followed PD group. The authors found no repeats in the premutation range (55-200 CGG repeats) and no significant difference in the proportion of intermediate-size (41-54 CGG repeats) carriers between the PD and the control groups. Using linear regression, the number of CGG repeats was not related to motor or cognitive progression. However, the marked cognitive decline in 2 patients carrying intermediate-size alleles points to a possible association. More studies with larger PD samples are warranted. (J Geriatr Psychiatry Neurol 2007;20:89-92)

Key Words: parkinsonism • Parkinson's disease • fragile X • FMR1 • dementia • cognitive decline

Journal of Geriatric Psychiatry and Neurology, Vol. 20, No. 2, 89-92 (2007)
DOI: 10.1177/0891988706297737


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