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Journal of Geriatric Psychiatry and Neurology, Vol. 20, No. 2, 93-99 (2007)
DOI: 10.1177/0891988706298627
© 2007 SAGE Publications

Polymorphisms and Vascular Cognitive Impairment After Ischemic Stroke

Larry Baum, PhD

Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, lwbaum{at}cuhk.edu.hk

Xiangyan Chen, MD

Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Shatin, Hong Kong

Wing Sze Cheung, BSc

Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Shatin, Hong Kong

Chi Kin Arthur Cheung, MBChB

Professional Programme of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong

Lap Woon Cheung, MBChB

Professional Programme of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong

Ka Fung Peter Chiu, MBChB

Professional Programme of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong

Hong Mei Wen, PhD

Department of Rehabilitation, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, P.R. China

Peter Poon, MPhil

Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong

Kam Sang Woo, MD

Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong

Ho Keung Ng, FRCPath

Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Shatin, Hong Kong

Ka Sing Wong, MD

Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong

Environmental and genetic factors may both affect the risk of vascular cognitive impairment developing after a stroke. To identify factors affecting this risk, the cognitive status of 121 patients was examined 3 months after an ischemic stroke. In all patients and in 270 control subjects, 7 polymorphisms reported to affect risk of vascular ischemic disease were genotyped. In 51 patients (42.1%), vascular cognitive impairment resulted, defined by a Mini-Mental State Examination score of less than 24. These patients were older and more likely to be women. Alleles of none of the polymorphisms differed between patients with or without vascular cognitive impairment, except for glutamate-cysteine ligase modifier (GCLM) (odds ratio = 2.8, P = .006). When all stroke patients were considered, the GCLM genotype did not affect Mini-Mental State Examination scores. Testing the GCLM genotype in an independent group of stroke patients may determine whether this association with vascular cognitive impairment is genuine. ( J Geriatr Psychiatry Neurol 2007;20:93-99)

Key Words: apolipoprotein E • lipoprotein lipase • glutamate-cysteine ligase modifier • ischemic stroke • dementia


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