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Characterization of the Lipid Profile in Dementia and Depression in the Elderly

University of Athens

Christina Piperi, BSc, PhD

Laboratory of Biological Chemistry, University of Athens Medical School, M. Asias 75, Biological Chemistry, Universi Goudi 11527, Athens, Greece, cpiperi{at}med.uoa.gr

Aristea Salonicioti

University of Athens

Vassiliki Psarra, MD

University of Athens

Charalampos Mitsonis, MD

University of Athens

Ioannis Liappas, MD, PhD

University of Athens

Robert W. Lea, PhD

University of Athens

Anastasios Kalofoutis, MD, PhD

University of Athens

The purpose of the study was to examine the association of plasma lipid concentrations with changes in cognitive function and depressive states in elderly Greek individuals. The study population consisted of 3 groups: A) 37 subjects with dementia, B) 33 subjects with depression, and C) 33 controls. All individuals were screened with the Mini-Mental State Examination (MMSE), the Geriatric Depression Scale (GDS), and an evaluation of their psychiatric state. Lipid profile was assessed in all subjects, and the results were statistically evaluated at P < .05 level of significance. Groups A and B had significantly lower levels of total plasma cholesterol and HDL cholesterol than group C (P < .01). Triglyceride levels did not differ significantly between groups A and C, although they were significantly higher in group B. The results of this study suggest that an association does exist between the plasma concentration of cholesterol and HDL-C and depression and/or cognitive impairment. Further studies are required to explore the significance of these observations and establish if lipid levels could serve as markers for diagnostic and therapeutic purposes. (J Geriatr Psychiatry Neurol 2007;20:138-144)

Key Words: dementia • depression • elderly • lipids

Journal of Geriatric Psychiatry and Neurology, Vol. 20, No. 3, 138-144 (2007)
DOI: 10.1177/0891988707301867


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