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Journal of Geriatric Psychiatry and Neurology
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Clozapine for Treatment-Resistant Agitation in Dementia

Hochang B. Lee, MD

The Johns Hopkins University School of Medicine, 550 N Broadway, Suite 308, Baltimore, MD 21205, hochang{at}jhmi.edu

Jennifer A. Hanner, MD, MPH

Jessica L. Yokley, BA

Brian Appleby, MD

Lisa Hurowitz, PharmD

Constantine G. Lyketsos, MD, MHS

Few studies have examined the potential role of clozapine in treatment of agitation in dementia patients who have previously failed to respond to standard pharmacotherapy. We conducted a systematic chart review of all elderly patients admitted to our inpatient unit between 2001 and 2004. Of them, 16 dementia patients were treated with clozapine for treatment-resistant agitation, and their charts were blindly rated by 3 clinicians on the Clinical Global Impression (CGI) Scale, Brief Agitation Rating Scale (BARS), and the Cohen-Mansfield Agitation Inventory-Short Form (CMAI-SF). Overall, clozapine therapy seemed beneficial in treatment-resistant agitation in dementia patients. (J Geriatr Psychiatry Neurol 2007;20:178—182)

Key Words: agitation • dementia • clozapine • treatment

Journal of Geriatric Psychiatry and Neurology, Vol. 20, No. 3, 178-182 (2007)
DOI: 10.1177/0891988707303335
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