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Lack of Association Between Apolipoprotein E Polymorphism and Vascular Dementia in Koreans

Department of Neuropsychiatry and Stroke Center, Seoul National University Bundang Hospital, Seongnam, Department of Psychiatry, Seoul National University College of Medicine

Jong-Chul Youn, MD

Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Gyeonggi-do

Moon-Ku Han, MD, PhD

Department of Neurology, Seoul National University Bundang

Nam Jong Paik, MD, PhD

Department of Rehabilitation, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do

Tae Joo Lee, MD

Department of Neuropsychiatry and Stroke Center, Seoul National University Bundang Hospital, Seongnam

Joon Hyuk Park, MD

Department of Neuropsychiatry and Stroke Center, Seoul National University Bundang Hospital, Seongnam

Seok Bum Lee, MD

Department of Neuropsychiatry and Stroke Center, Seoul National University Bundang Hospital, Seongnam

Il Han Choo, MD

Department of Neuropsychiatry, Seoul National University Hospital, Seoul

Dong Young Lee, MD, PhD

Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Department of Psychiatry, Seoul National University College of Medicine

Jin Hyeong Jhoo, MD, PhD

Department of Neuropsychiatry, Kangwon National University Hospital, Kangwondo

Jong Inn Woo, MD, PhD

Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Department of Psychiatry, Seoul National University College of Medicine, Neuroscience Research Institute of Medical Research Center, Seoul National University Seoul, Korea, jiwoomd{at}snu.ac.kr

To investigate an association of vascular dementia (VD) with the apolipoprotein E (APOE) polymorphism, the APOE polymorphism of 100 VD patients, 100 age- and gender-matched Alzheimer disease (AD) patients, and 200 age- and gender-matched nondemented control (NC) subjects was genotyped. The distribution of APOE polymorphism was compared. Neither the APOE 4 allele nor the APOE 2 allele was more prevalent in the VD patients compared with the NC subjects (P > .1 by the ² test), which was the case when both men and women were analyzed separately (P > .1 by the ² test) and when young patients (75 years old or less) and old patients (more than 75 years old) were analyzed separately (P > .1 by the ² test). The estimated statistical power was over 0.80 when the odds ratios (OR) for VD conferred to the APOE 4 are assumed to be higher than 2.2 and the type I error probability is set at 0.05, which is much higher than the power of the previous studies on the VD/APOE association. In conclusion, the results suggested that APOE 4 allele does not confer the risk for VD, and even if it does, it does so very modestly.

Key Words: vascular dementia • Alzheimer disease • apolipoprotein E • polymorphism • association

Journal of Geriatric Psychiatry and Neurology, Vol. 21, No. 1, 12-17 (2008)
DOI: 10.1177/0891988707311028


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