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Journal of Geriatric Psychiatry and Neurology, Vol. 21, No. 1, 47-55 (2008)
DOI: 10.1177/0891988707311564
© 2008 SAGE Publications

Patterns of Depression in Spanish- and English-Speaking Patients With Alzheimer's Disease

Raymond L. Ownby, MD, PhD, MBA

Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, The Wien Center for Alzheimer's Disease and Memory Disorders, Mt. Sinai Medical Center, Miami Beach, Florida, rownby{at}med.miami.edu

Amarilis Acevedo, PhD

Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, The Wien Center for Alzheimer's Disease and Memory Disorders, Mt. Sinai Medical Center, Miami Beach, Florida

Dylan G. Harwood, PhD

Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, The Wien Center for Alzheimer's Disease and Memory Disorders, Mt. Sinai Medical Center, Miami Beach, Florida

Warren W. Barker, MA

Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, The Wien Center for Alzheimer's Disease and Memory Disorders, Mt. Sinai Medical Center, Miami Beach, Florida

Ranjan Duara, MD

Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, The Wien Center for Alzheimer's Disease and Memory Disorders, Mt. Sinai Medical Center, Miami Beach, Florida

The purpose of this study was to evaluate whether distinct subtypes of depression could be identified in patients with Alzheimer's disease and, if so, to evaluate the patients in these subgroups. Ratings on the Cornell Scale for Depression in Dementia (CSDD) of 306 patients with Alzheimer's disease, 129 of whom were Spanish- and 177 English-speaking, were subjected to latent class analysis. Four subgroups were identified based on CSDD symptoms. These included an asymptomatic group, groups with mild and more severe typical depression, and a group characterized by prominent anxiety and irritability in addition to sadness. Group differences on demographic, cognitive, clinical, and functional status measures were explored via chi-square tests and analyses of variance. Results show that for some patients with Alzheimer's disease, patterns of symptoms of depression are similar to those in younger adult populations. A distinct subtype may exist, however, with prominent anxiety and irritability.

Key Words: Alzheimer's disease • depression • latent class analysis


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