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The Importance of Alzheimer Disease Assessment Scale-cognitive Part in Predicting Progress for Amnestic Mild Cognitive Impairment to Alzheimer Disease

Department of Neurology, University of Brescia, Italy, Geriatric Research Group, via Romanino 1, 25100 Brescia, Italy, lrozzini{at}iol.it

Barbara Vicini Chilovi, MD

Department of Neurology, University of Brescia, Italy, Geriatric Research Group, via Romanino 1, 25100 Brescia, Italy

Erik Bertoletti, MD

Department of Neurology, University of Brescia, Italy

Marta Conti, MD

Department of Neurology, University of Brescia, Italy

Ilenia Delrio, MD

Department of Neurology, University of Brescia, Italy

Marco Trabucchi, MD, PhD

Geriatric Research Group, via Romanino 1, 25100 Brescia, Italy

Alessandro Padovani, MD, PhD

Department of Neurology, University of Brescia, Italy

The aim of this study was to verify the usefulness of Alzheimer Disease Assessment Scale-cognitive subscale (ADAS-Cog), in screening participants at risk of developing Alzheimer disease (AD) among populations with amnestic mild cognitive impairment(aMCI). 98 outpatients with aMCI were recruited. Participants were revaluated after 1 year: 44 (44.9%) were progressed to AD (progressors), while 54 (55.1%) did not convert (nonprogressors MCI). At baseline, cognitive performances were more impaired in progressors assessed by MMSE and by a neuropsychological battery. When tested with the ADAS-Cog subscale, the 2 groups of participants at baseline, progressors, and nonprogressors MCI, were significantly different regarding total score, memory, and nonmemory subitems. Considering a cutoff of 9.5 total score, adjusted for education, ADAS-Cog subscale showed a good performance (area under the curve = 0.67; sensitivity = 0.62%; specificity = 0.73%) in predicting conversion from aMCI to AD. Progressors aMCI were characterized at baseline by a greater cognitive impairment. ADAS-Cog subscale is a useful and brief cognitive assessment tool to screen aMCI participants converting to AD within 1 year.

Key Words: mild cognitive impairment • MCI • Alzheimer Disease Assessment Scale-cognitive part • ADAS-Cog • Alzheimer disease • AD • dementia

Journal of Geriatric Psychiatry and Neurology, Vol. 21, No. 4, 261-267 (2008)
DOI: 10.1177/0891988708324940


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