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Association of ACE I/D Gene Polymorphism With Vascular Dementia: A Meta-Analysis

Department of Neurology, West China Hospital, Sichuan University, Sichuan Province, P R China, Department of Neurology the First Affiliated Hospital of Kunming Medical College, Kunming City, Yunnan Province, P R China

Ming Liu, MD

Department of Neurology, West China Hospital, Sichuan University, Sichuan Province, P R China, Key Laboratory of Human Disease Biotherapy of the State and Ministry of Education, West China Hospital, Sichuan University, Sichuan Province, P R China, wyplmh{at}hotmail.com

Wei Li, MD

Department of Neurology, West China Hospital, Sichuan University, Sichuan Province, P R China

Bo Wu, MD, PhD

Department of Neurology, West China Hospital, Sichuan University, Sichuan Province, P R China

Shi-hong Zhang, MD

Department of Neurology, West China Hospital, Sichuan University, Sichuan Province, P R China

Yuan Fang, MD

Department of Neurology, West China Hospital, Sichuan University, Sichuan Province, P R China

Yi Wang, MD

Department of Neurology Hua Shan Hospital, FuDan University, Shanghai, P R China

Background: Vascular dementia is the second common cause of dementia, only second to Alzheimer's disease in later life, and has a greater mortality risk than Alzheimer's disease among the elderly population group. The angiotensin-converting enzyme insertion/deletion polymorphism as a risk factor in vascular dementia has been suggested, but direct evidence from genetic association studies remain inconclusive. We performed a meta-analysis pooling data from all relevant studies in order to determine the effect of the insertion/deletion polymorphism on the vascular dementia.

Methods: We applied a random-effects model or fixed-effects model to combine odds ratio and 95% confidence intervals. Q statistic was used to evaluate the homogeneity, and Egger's test and Funnel plot were used to assess publication bias.

Results: A total of 10 studies were included worldwide. Publication bias was not observed. There was no evidence of the association of angiotensin-converting enzyme insertion/deletion polymorphism with the vascular dementia in general or in the Asian populations or in the Caucasian populations. Conclusions: The angiotensin-converting enzyme insertion/deletion polymorphism might be neutral to vascular dementia.

Key Words: ACE • ACE gene polymorphism • vascular dementia • VD • meta-analysis • systematic review

This version was published on March 1, 2009

Journal of Geriatric Psychiatry and Neurology, Vol. 22, No. 1, 10-22 (2009)
DOI: 10.1177/0891988708328221


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