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Association Between Cytokines and Cerebral MRI Changes in the Aging Brain

Department of Psychiatry School of Medicine, James Cook University, Queensland, Australia, Bernhard.Baune{at}jcu.edu.au

Gerald Ponath, PhD

Department of Psychiatry, University of Muenster, Muenster Germany

Matthias Rothermundt, MD

Department of Psychiatry, University of Muenster, Muenster Germany

Andreas Roesler, MD

Department of Neuroradiology (AR), Central Hospital, Augsburg, Germany

Klaus Berger, MD, MPH

Institute of Epidemiology and Social Medicine, University of Muenster Muenster, Germany

The association between cytokines (IL-1β, sIL-4R, IL-6, IL-8, IL-10, IL-12, TNF-) and subcortical white matter lesions, cortical atrophy and lacunar infarctions of the aging brain was investigated among 268 elderly community participants. Single pro- and anti-inflammatory cytokines were neither associated with WML nor with atrophy and lacunar infarction. An association between atrophy and the chemokine-cytokine factor (containing sIL-4R, IL-6, IL-8) remained significant after adjustment for age, gender, education, depressive symptoms, diabetes mellitus, cardiovascular diseases (stroke, TIA, myocardial infarction, myocardial insufficiency, arrhythmic heart), hypertension, body-mass index, smoking status and aggregation inhibitors as opposed to single cytokines. Atrophy of the parietal, temporal and occipital lobes was associated with the same cytokinechemokine factor for both the whole sample or restricted to those without history of stroke/TIA. The results indicate that a combination of chemokine-cytokines rather than single cytokines may contribute to inflammatory processes associated with cortical atrophy in the aging brain.

Key Words: white matter lesions • atrophy • lacunar infarctions • aging • cytokines

This version was published on March 1, 2009

Journal of Geriatric Psychiatry and Neurology, Vol. 22, No. 1, 23-34 (2009)
DOI: 10.1177/0891988708328216


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