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Alterations in Regional Brain Volume and Individual MRI-Guided Perfusion in Normal Control, Stable Mild Cognitive Impairment, and MCI-AD Converter

Department of Geriatric Psychiatry, Peking University Institute of Mental Health, Beijing, China, Tu and Yuen Center for Functional Onco-Imaging

Edward Golob, PhD

Department of Psychology, Tulane University, New Orleans, Louisiana

Alberto Bert, PhD

Department of Physics, University of California, Irvine California

Ke Nie, MS

Tu and Yuen Center for Functional Onco-Imaging, University of California, Irvine California, Department of Physics, University of California, Irvine California

Yong Chu, PhD

Malcolm B. Dick, PhD

Institute for Brain Aging and Dementia, University of California, Irvine California

Mark Mandelkern, MD, PhD

Tu and Yuen Center for Functional Onco-Imaging, University of California, Irvine California, Department of Physics, University of California, Irvine California

Min-Ying Su, PhD

Tu and Yuen Center for Functional Onco-Imaging, University of California, Irvine California, msu{at}uci.edu

Regional differences in tissue volume and perfusion in brains of individuals with mild cognitive impairment (MCI) versus normal healthy age-matched controls (NC), and the differences between MCI-AD converters and stable MCI patients were investigated. MRI and SPECT scans were performed on 13 MCI (74+6 years) and 12 NC (75+4 years). Of the MCI patients, 10 were followed for up to three years and 4 subsequently converted to Alzheimer's disease (AD). Episodic memory function was assessed using tests of delayed recall for word lists and stories. The volume reductions and hypoperfusion were mainly confined to the medial temporal lobe (MTL) of MCI patients and associated with worse scores on memory tests. Perfusion in the corpus callosum and the gray matter of frontal, lateral temporal, parietal or occipital lobe was not significantly affected in MCI. The 4 MCI-AD converters had relatively low MTL structural volume and perfusion compared to their stable peers.

Key Words: mild cognitive impairment • medial temporal lobe • perfusion • volume • memory-function

This version was published on March 1, 2009

Journal of Geriatric Psychiatry and Neurology, Vol. 22, No. 1, 35-45 (2009)
DOI: 10.1177/0891988708328212


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