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Impaired Social Cognition in Mild Alzheimer Disease

Université de Lyon, Lyon, F-69003, France, benoit.bediou{at}cisa.unige.ch, IFR19, Bron, F-69500, France, Université de Lyon, EA 4166 Lyon, France, Centre Hospitalier « Le Vinatier », Bron, F-69677, France

Ilham Ryff, MSc

Hospices Civils de Lyon, Hôpital neurologique, Service de Neurologie, Lyon, F-69003, France

Bernadette Mercier, MSc

Hospices Civils de Lyon, Hôpital neurologique, Service de Neurologie, Lyon, F-69003, France

Maud Milliery, MSc

Hospices Civils de Lyon, Hôpital neurologique, Service de Neurologie, Lyon, F-69003, France

Marie-Anne Hénaff, MSc

IFR19, Bron, F-69500, France, Inserm U821, Centre hospitalier Le Vinatier, Bron, F-69677, France

Thierry D'Amato, MD, PhD

IFR19, Bron, F-69500, France, Université de Lyon, Lyon, F-69003, France, Centre Hospitalier « Le Vinatier », Bron, F-69677, France, Université de Lyon, EA 4166 Lyon, France

Marc Bonnefoy, MD, PhD

IFR19, Bron, F-69500, France, Université de Lyon, Lyon, F-69003, France, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Service de Médecine Gériatrique, Lyon, F-69003, France

Alain Vighetto, MD, PhD

IFR19, Bron, F-69500, France, Université de Lyon, Lyon, F-69003, France, Hospices Civils de Lyon, Hôpital neurologique, Service de Neurologie, Lyon, F-69003, France

Pierre Krolak-Salmon, MD, PhD

IFR19, Bron, F-69500, France, Université de Lyon, Lyon, F-69003, France, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Service de Médecine Gériatrique, Lyon, F-69003, France, Inserm U821, Centre hospitalier Le Vinatier, Bron, F-69677, France

Abnormal decoding of social information has been associated with the conversion from prodromal Alzheimer's disease (AD) to dementia. Since the distributed neural networks involved in face processing are differentially affected in prodromal and dementia states of AD and in Fronto-Temporal Dementia (FTD), we hypothezed a differential impairment in face processing in these populations. Facial expression, gender and gaze direction decoding abilities were examined in patients with probable amnesic Mild Cognitive Impairment (aMCI, N = 10) fulfilling criteria for prodromal AD, in patients with mild and moderate AD (N = 10) as well as in FTD patients (N = 10) and in a group of age- and sex-matched healthy comparison subjects (N = 10). Gender recognition was preserved in all groups. Compared to controls, patients with mild or moderate AD were impaired in expression recognition and FTD patients were impaired in expression and gaze direction determination, whereas MCI patients were not impaired at all.

Key Words: social cognition • face processing • Alzheimer disease • frontotemporal dementia • mild cognitive impairment • temporal lobe

This version was published on June 1, 2009

Journal of Geriatric Psychiatry and Neurology, Vol. 22, No. 2, 130-140 (2009)
DOI: 10.1177/0891988709332939


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