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APOE Alleles in Parkinson Disease and Their Relationship to Cognitive Decline: A Population-based, Longitudinal Study

The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway, kuma{at}sus.no, Department of Neurology, Stavanger University Hospital, Stavanger, Norway

Gabriele Dekomien, PhD

Department of Human Genetics, Ruhr-University, Bochum, Germany

Odd Bjarte Nilsen, PhD

The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway

Jan Petter Larsen, MD, PhD

University of Bergen, Institute of Clinical Medicine, Bergen, Norway, The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway, Department of Neurology, Stavanger University Hospital, Stavanger, Norway

Dag Aarsland, MD, PhD

King's College London, Wolfson Centre for Age-Related Diseases, London, UK, University of Bergen, Institute of Clinical Medicine, Bergen, Norway, The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway

Guido Alves, MD, PhD

The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway, Department of Neurology, Stavanger University Hospital, Stavanger, Norway

Apolipoprotein E gene alleles have been linked to various cardiovascular and neurodegenerative disorders. There have been conflicting reports of associations between Apolipoprotein E alleles and Parkinson disease and Parkinson disease dementia. To investigate the role of Apolipoprotein E alleles in Parkinson disease and Parkinson disease dementia, we have determined Apolipoprotein E genotypes in a group of patients with Parkinson disease (n = 95) and compared them with those of healthy control participants (n = 73). Additionally, in 64 longitudinally followed patients with Parkinson disease, the allele types were correlated to development and progression of dementia and to time from onset of Parkinson disease to dementia using multivariate and survival analyses. The Apolipoprotein E e4e4 genotype was more common in patients with Parkinson disease (7.4%) than in healthy controls (1.4%; P = .03). No significant associations between the Apolipoprotein E genotype and development and progression of dementia or time to dementia were found. More studies with larger Parkinson disease samples are warranted.

Key Words: Parkinson disease • dementia • genetics • apolipoprotein E • cognitive decline

This version was published on September 1, 2009

Journal of Geriatric Psychiatry and Neurology, Vol. 22, No. 3, 166-170 (2009)
DOI: 10.1177/0891988709332945


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