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Serum 25-Hydroxyvitamin D Concentration and Cognitive Impairment

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK, dl355{at}medschl.cam.ac.uk

Kenneth M. Langa, MD, PhD

Department of Internal Medicine, and Institute for Social Research, University of Michigan, Michigan, Veterans Affairs Center for Practice Management and Outcomes Research, Michigan

Iain A. Lang, PhD

Public Health and Epidemiology Group, Peninsula Medical School, Exeter, UK

Vitamin D may be of interest in the prevention of cognitive impairment, though previous findings are inconclusive. Participants were 1766 adults aged 65 years and older from the Health Survey for England 2000, a nationally representative population-based study. Cognitive impairment was assessed using the Abbreviated Mental Test Score. The cross-sectional relation of serum 25-hydroxyvitamin D quartiles to cognitive impairment was modeled using logistic regression. In all, 212 participants (12%) were cognitively impaired. Odds ratios (95% confidence intervals) for cognitive impairment in the first (8-30 nmol/L), second (31-44 nmol/L), and third (45-65 nmol/L) quartiles of serum 25-hydroxyvitamin D compared with the fourth (66-170 nmol/L) were 2.3 (1.4-3.8), 1.4 (0.8-2.4), and 1.1 (0.6-1.9), after adjustment for age, sex, education, ethnicity, season of testing, and additional risk factors for cognitive impairment (P for linear trend = .001). Our data suggest low serum 25-hydroxyvitamin D is associated with increased odds of cognitive impairment.

Key Words: cognitive impairment • dementia • risk factors • vitamin D • serum 25-hydroxyvitamin D

This version was published on September 1, 2009

Journal of Geriatric Psychiatry and Neurology, Vol. 22, No. 3, 188-195 (2009)
DOI: 10.1177/0891988708327888


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