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Assessment of Behavioral and Affective Symptoms in Alzheimer's Disease

Department of Neurology and Psychiatry, School of Medicine, Department of Psychology, Case Western Reserve University, University Hospitals of Cleveland Alzheimer Center, Cleveland, OH

Audrey H. Schnell

University Hospitals of Cleveland Alzheimer Center, Cleveland, OH

Richard J. Martin

Frances Payne Bolton School of Nursing, Case Western Reserve University, University Hospitals of Cleveland Alzheimer Center, Cleveland, OH

Mario F. Mendez

University Hospitals of Cleveland Alzheimer Center, Cleveland, OH, Department of Neurology, Case Western Reserve University

Kathleen A. Smyth

Department of Epidemiology and Biostatistics, School of Medicine, Departmet of Sociology, Case Western Reserve University

Peter J. Whitehouse

University Hospitals of Cleveland Alzheimer Center, Cleveland, OH, Department of Neurology, Case Western Reserve University

Noncognitive behavioral symptoms occurring during the prior week were studied in 34 Alzheimer's disease (AD) patients and 21 spousal control subjects via caregiver and patient interviews using the Behavioral Pathology in Alzheimer's Disease Rating Scale and the Cornell Scale for Depression in Dementia. Delusional or paranoid features were reported in 13 subjects (38%) and hallucinations in six (18%); patients with these psychoticlike symptoms had lower scores on the Folstein's Mini-Mental State Examination. Other behavioral symptoms reported in AD patients included anxiety (50%) and activity disturbances (44%). Six AD subjects (18%) and two controls (10%) showed mild to moderate symptoms of depression ; AD subjects were more likely than controls to show behavioral signs and symptoms of depression, but the two groups did not differ in terms of mood-related, cyclical, or physical signs and symptoms. (J Geriatr Psychiatry Neurol 1990;3:21-30).

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