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Journal of Geriatric Psychiatry and Neurology
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Hydergine Treatment and Psychophysiological Measures in Primary Degenerative Dementia

Michael A. Kuskowski

Geriatric Research, Education and Clinical Center

Gerald Morley

Neurology Service, Veterans Administration Medical Center, Minneapolis, Minnesota

Stephen M. Malone

Neurology Service, Veterans Administration Medical Center, Minneapolis, Minnesota

Maurice W. Dysken

Geriatric Research, Education and Clinical Center, Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota

Amy Okaya

Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota

Changes in smooth pursuit eye movements and the P300 component of the auditory evoked potential were studied in patients with primary degenerative dementia during a double-blind, placebo-controlled study of ergoloid mesylates (Hydergine). After 18 weeks of treatment, P300 latency and amplitude, recorded at three scalp electrode sites, had not changed significantly. Smooth pursuit gain was elevated for the drug group under some stimulus conditions, suggesting a normalization of pursuit eye movement functioning. However, the results of several other measures of the quality of pursuit eye movements failed to corroborate this finding. (J Geriatr Psychiatry Neurol 1990; 3:41-47).

Journal of Geriatric Psychiatry and Neurology, Vol. 3, No. 1, 41-47 (1990)
DOI: 10.1177/089198879000300109
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