This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Kawabata, K. Articles by Sugita, M. Search for Related Content PubMed Articles by Kawabata, K. Articles by Sugita, M. Social Bookmarking                         What's this?

Cerebral Blood Flow and Dementia in Parkinson's Disease

Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

Hisao Tachibana, MD

Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

Minoru Sugita, MD

Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

Regional cerebral blood flow (CBF) was examined in 27 patients with Parkinson's disease using single-photon emission computed tomography and N-isopropyl-p-[¹²³I]iodoamphetamine as a tracer. Their CBF pattern was compared with that of seven patients with Alzheimer's disease and nine age-matched neurologically normal controls. Tracer activity was determined in seven bilateral cerebellar, cortical, and subcortical regions and was expressed as the ratio of activity in each region to the mean tracer activity in the cerebellar region.

Nineteen patients with nondemented Parkinson's disease showed significantly decreased tracer activity ratio in the frontal and temporal cortices, basal ganglia, and thalamus compared with that in controls. The eight demented Parkinson's disease patients showed significantly decreased tracer activity ratio in the temporal and parietal cortices compared with the patients without dementia, and demonstrated CBF pattern similar to that of patients with Alzheimer's disease. These findings suggest that in patients with Parkinson's disease, the mechanism of CBF reduction of the frontal cortical region differs from that in the temporoparietal cortical region and support the concept that Parkinson's disease and Alzheimer's disease may overlap in some patients. (J Geriatr Psychiatry Neurol 1991;4:194-203).

Journal of Geriatric Psychiatry and Neurology, Vol. 4, No. 4, 194-203 (1991)
DOI: 10.1177/089198879100400404


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				B. Okuda, H. Tachibana, K. Kawabata, M. Takeda, and M. Sugita Cerebral Blood Flow Correlates of Higher Brain Dysfunctions in Corticobasal Degeneration J Geriatr Psychiatry Neurol, December 1, 1999; 12(4): 189 - 193. [Abstract] [PDF]

				M. S. Nobler, G. H. Pelton, and H. A. Sackeim Cerebral Blood Flow and Metabolism in Late-Life Depression and Dementia J Geriatr Psychiatry Neurol, October 1, 1999; 12(3): 118 - 127. [Abstract] [PDF]