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Quantitative Assessment of ALZ-50 Immunoreactivity in Alzheimer's Disease

Neurology Service Massachusetts General Hospital, Boston, MA

J.E. Flory, BA

Department of Anatomy and Neurology, University of Iowa College of Medicine, Iowa City, IA

S.E. Arnold, MD

Department of Pathology (Neuropathology) University of Iowa College of Medicine, Iowa City, IA

G.W. Van Hoesen, PhD

Department of Anatomy and Neurology, University of Iowa College of Medicine, Iowa City, IA, Department of Pathology (Neuropathology) University of Iowa College of Medicine, Iowa City, IA

R.L. Schelper, MD, PhD

Department of Pathology, University of Iowa College of Medicine, Iowa City, IA

H. Ghanbari, PhD

Department of Psychiatry University of Pennsylvania, Philadelphia, PA

H. Haigler, PhD

Mental Illnesses and Neurological Disorder Diagnostics Abbott Laboratories, Abbott Park, IL

A quantitative assay for ALZ-50 immunoreactivity was evaluated in samples of superior temporal gyrus taken at autopsy from 13 Alzheimer patients and 11 controls. The assayable immunoreactivity appears to be stable for at least 24 hours postmortem but was lost with formalin fixation. The mean value of the Alzheimer patients was tenfold higher than that of the controls (P < .002). The values of four Alzheimer samples overlapped with the low levels seen in controls, but no controls had elevated levels. In this sample population, therefore, the assay had a sensitivity of 69% and specificity of 100%. (J Geriatr Psychiatry Neurol 1991;4:231-235).

Journal of Geriatric Psychiatry and Neurology, Vol. 4, No. 4, 231-235 (1991)
DOI: 10.1177/089198879100400410


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