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Journal of Geriatric Psychiatry and Neurology
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Weight Loss in Alzheimer's Disease

Wei Du, PhD

Department of Neurology, Massachusetts General Hospital, Boston, MA.

Chiara DiLuca, MD

Department of Neurology, Massachusetts General Hospital, Boston, MA.

John H. Growdon, MD

Department of Neurology, Massachusetts General Hospital, Boston, MA.

In order to determine whether weight loss is a core symptom or secondary manifestation of Alzheimer's disease, we analyzed weight change in 81 outpatients with Alzheimer's disease. During a mean 2.9 years of observation, the mean absolute weight loss was 1.9 ± 0.8 kg, and the mean weight loss per year was 0.7 ± 0.3 kg. Although statistically significant (P < .05), the mean absolute weight loss was only 3% of initial body weight. Data analyses revealed that weight change was significantly (P < .0001) correlated with decreased independence in self-feeding. Weight change was not related to duration of dementia, clinical measures of dementia severity, psychiatric symptoms, or medications. These observations support the view that weight loss is a consequence of Alzheimer's disease and does not reflect specific brain lesions. (J Geriatr Psychiatry Neurol 1993;1:34–38).

Journal of Geriatric Psychiatry and Neurology, Vol. 6, No. 1, 34-38 (1993)
DOI: 10.1177/002383099300600106
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