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Single Photon Emission Computed Tomography in Dementia: Relationship of Perfusion to Cognitive Deficits

Department of Medicine (Dr Engel), University of Connecticut School of Medicine, Farmington, CT, the Departments of Neurology and Psychiatry and of Biobehavioral Sciences (Dr Cummings), University of California at Los Angeles (UCLA) School of Medicine and the Behavioral Neuroscience Section, Psychiatry Service, West Los Angeles, Veterans Affairs Medical Center, Los Angeles, CA, and the Department of Nuclear Medicine (Drs Villanueva-Meyer and Mena), Harbor-UCLA Medical Center, Los Angeles, CA.

Jeffrey L. Cummings, MD

Department of Medicine (Dr Engel), University of Connecticut School of Medicine, Farmington, CT, the Departments of Neurology and Psychiatry and of Biobehavioral Sciences (Dr Cummings), University of California at Los Angeles (UCLA) School of Medicine and the Behavioral Neuroscience Section, Psychiatry Service, West Los Angeles, Veterans Affairs Medical Center, Los Angeles, CA, and the Department of Nuclear Medicine (Drs Villanueva-Meyer and Mena), Harbor-UCLA Medical Center, Los Angeles, CA.

Javier Villanueva-Meyer, MD

Department of Medicine (Dr Engel), University of Connecticut School of Medicine, Farmington, CT, the Departments of Neurology and Psychiatry and of Biobehavioral Sciences (Dr Cummings), University of California at Los Angeles (UCLA) School of Medicine and the Behavioral Neuroscience Section, Psychiatry Service, West Los Angeles, Veterans Affairs Medical Center, Los Angeles, CA, and the Department of Nuclear Medicine (Drs Villanueva-Meyer and Mena), Harbor-UCLA Medical Center, Los Angeles, CA.

Ismael Mena, MD

Department of Medicine (Dr Engel), University of Connecticut School of Medicine, Farmington, CT, the Departments of Neurology and Psychiatry and of Biobehavioral Sciences (Dr Cummings), University of California at Los Angeles (UCLA) School of Medicine and the Behavioral Neuroscience Section, Psychiatry Service, West Los Angeles, Veterans Affairs Medical Center, Los Angeles, CA, and the Department of Nuclear Medicine (Drs Villanueva-Meyer and Mena), Harbor-UCLA Medical Center, Los Angeles, CA.

Sixteen patients with dementia (nine with Alzheimer's disease and seven with multi-infarct dementia) were studied with xenon-133 and hexamethyl-propyleneamine-oxime single photon emission computed tomography (SPECT). Quantification of cerebral blood flow was determined in 16 hemispheric regions of interest. Neuropsychological deficits were assessed with the Mini-Mental State Examination and the Neurobehavior Cognitive Status Examination. Alzheimer's disease patients had symmetric reduction of parietal lobe perfusion; multi-infarct dementia patients had multifocal perfusion deficits. Correlations were demonstrated between cerebral blood flow in the posterior brain regions and performance on tests of language, memory, attention, figure copying, judgment, and similarities. Alzheimer's disease patients exhibited more language impairment than multi-infarct dementia patients. SPECT promises to provide diagnostic information and data relevant to interpretation of neuropsychological deficits.

Journal of Geriatric Psychiatry and Neurology, Vol. 6, No. 3, 144-151 (1993)
DOI: 10.1177/089198879300600303


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