This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Schulz, H. Articles by Jobert, M. Search for Related Content PubMed PubMed Citation Articles by Schulz, H. Articles by Jobert, M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Antidepressants Hazardous Substances DB PERYLENE QUERCETIN Social Bookmarking                         What's this?

Effects of Hypericum Extract on the Sleep EEG in Older Volunteers

M. Jobert

The effects of treatment with high doses (300 mg three times daily) of hypericum extract LI 160 on sleep quality and well-being were investigated over a 4-week period. The double-blind, placebo-controlled study was conducted with 12 older, healthy volunteers in a cross-over design, which included a 2-week wash-out phase between both treatment phases. A hypostatic influence of the REM sleep phases, which is typical for tricyclic antidepressants and MAO inhibitors, could not be shown for this phytopharmacon. Instead, LI 160 induced an increase of deep sleep during the total sleeping period. This could be shown consistently in the visual analysis of the sleeping phases 3 and 4, as well as in the automatic analysis of slow-wave EEG activities. The continuity of sleep was not improved by LI 160; this was also the case for the onset of the sleep, the intermittent wake-up phases, and total sleep duration. (J Geriatr Psychiatry Neurol 1994; 7(suppl 1): S39-S43).

Journal of Geriatric Psychiatry and Neurology, Vol. 7, No. 1, S39-S43 (1994)
DOI: 10.1177/089198879400700111


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				P. J. Nathan Hypericum perforatum (St John's Wort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology J Psychopharmacol, January 1, 2001; 15(1): 47 - 54. [Abstract] [PDF]

				G. Harrer and V. Schulz Clinical Investigation of the Antidepressant Effectiveness of Hypericum J Geriatr Psychiatry Neurol, October 1, 1994; 7(1): S6 - S8. [Abstract] [PDF]

				W.-D. Hubner, S. Lande, and H. Podzuweit Hypericum Treatment of Mild Depressions with Somatic Symptoms J Geriatr Psychiatry Neurol, October 1, 1994; 7(1): S12 - S14. [Abstract] [PDF]

				H.-M. Thiede and A. Walper Inhibition of MAO and COMT by Hypericum Extracts and Hypericin J Geriatr Psychiatry Neurol, October 1, 1994; 7(1): S54 - S56. [Abstract] [PDF]