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Journal of Geriatric Psychiatry and Neurology
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Modulation of Cytokine Expression by Hypericum Extract

B. Thiele

I. Brink

M. Ploch

The effect of hypericum extract LI 160 on the stimulated cytokine expression was investigated in vitro in a whole blood culture system. Blood samples were taken from five healthy volunteers and four depressive patients. The release of interleukin-6 (IL-6), interleukin-1ß (IL-1ß) and tumor necrosis factor-{alpha} (TNF-{alpha}) was measured quantitatively after an incubation time of 24 hours on microtiter plates. A massive suppression of the interleukin-6 release was found for PHA-stimulated hypericum extract. Possible relations to the antidepressive effects of hypericum extract are discussed. (J Geriatr Psychiatry Neurol 1994; 7(suppl 1): S60-S62).

Journal of Geriatric Psychiatry and Neurology, Vol. 7, No. 1, S60-S62 (1994)
DOI: 10.1177/089198879400700116
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