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Journal of Geriatric Psychiatry and Neurology
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Treatment of Depression in Advanced Alzheimer's Disease Using Sertraline

Ladislav Volicer, MD, PhD

Departments of Pharmalogy, Psychiatry and Medicine (Dr. Volicer), Boston University Schoolf Medicine, Boston, Massachusetts and the Geriatric Research Educaon Clinical Center (Dr. Volicer, Ms. Rheaume, and Mr. Cyr), E.N. Fgers Memorial Veterans Hospital, Bedford, Massachusetts.

Yvette Rheaume, RN, BSN

Departments of Pharmalogy, Psychiatry and Medicine (Dr. Volicer), Boston University Schoolf Medicine, Boston, Massachusetts and the Geriatric Research Educaon Clinical Center (Dr. Volicer, Ms. Rheaume, and Mr. Cyr), E.N. Fgers Memorial Veterans Hospital, Bedford, Massachusetts.

Dale Cyr, MS, RPh

Departments of Pharmalogy, Psychiatry and Medicine (Dr. Volicer), Boston University Schoolf Medicine, Boston, Massachusetts and the Geriatric Research Educaon Clinical Center (Dr. Volicer, Ms. Rheaume, and Mr. Cyr), E.N. Fgers Memorial Veterans Hospital, Bedford, Massachusetts.

Effects of sertraline on the affect and food refusal of patients with advanced dementia of the Alzheimer type (DAT) are reported. Out of 10 patients with depressed affect, sertraline improved affect in eight. Six of these patients were also refusing food, and sertraline diminished food refusal in five of them. A case report of a patient who had a dramatic improvement in response to sertraline treatment is presented.

Journal of Geriatric Psychiatry and Neurology, Vol. 7, No. 4, 227-229 (1994)
DOI: 10.1177/089198879400700406
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