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Journal of Geriatric Psychiatry and Neurology
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Fluoxetine-Induced Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Geriatric Case Report and a Review of the Literature

Richard Druckenbrod, PharmD

Department of Pharmacy and Therapeutics, School of Pharmacy (Dr. Druckenbrod); and the Department of Psychiatry and Western Psychiatric Institute and Clinic, School of Medicine (Dr. Mulsant), University of Pittsburgh, Pittsburgh, Pennsylvania.

Benoit H. Mulsant, MD

Department of Pharmacy and Therapeutics, School of Pharmacy (Dr. Druckenbrod); and the Department of Psychiatry and Western Psychiatric Institute and Clinic, School of Medicine (Dr. Mulsant), University of Pittsburgh, Pittsburgh, Pennsylvania.

In a frail, elderly, depressed patient, hyponatremia can present a difficult diagnostic and management challenge. We report the case of a severely depressed 83-year-old woman presenting with severe hyponatremia, eventually attributed to a syndrome of inappropriate, antidiuretic hormone (SIADH) secretion induced by fluoxetine. This case is discussed in the context of the multiple potential causes of hyponatremia in an elderly depressed patient, with a focus on fluoxetine-induced SIADH, as reported in 9 other published cases.

Journal of Geriatric Psychiatry and Neurology, Vol. 7, No. 4, 254-256 (1994)
DOI: 10.1177/089198879400700412
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