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Journal of Geriatric Psychiatry and Neurology, Vol. 19, No. 1, 36-40 (2006)
DOI: 10.1177/0891988705284739

Impaired Visual Acuity as a Risk Factor for Visual Hallucinations in Parkinson’s Disease

Hideaki Matsui, MD

Department of Neurology, Sumitomo Hospital, Osaka, Japan, matsui-hideaki{at}sumitomo-hp.or.jp

Fukashi Udaka, MD, PhD

Department of Neurology, Sumitomo Hospital, Osaka, Japan

Akiko Tamura, MD

Department of Neurology, Sumitomo Hospital, Osaka, Japan

Masaya Oda, MD, PhD

Department of Neurology, Sumitomo Hospital, Osaka, Japan

Tamotsu Kubori, MD, PhD

Department of Neurology, Sumitomo Hospital, Osaka, Japan

Kazuto Nishinaka, MD, PhD

Department of Neurology, Sumitomo Hospital, Osaka, Japan

Masakuni Kameyama, MD, PhD

Department of Neurology, Sumitomo Hospital, Osaka, Japan

Pathophysiology of hallucinations in Parkinson’s disease is poorly understood. This study investigated relationships between visual hallucinations and visual acuity. Twenty-six consecutive patients with Parkinson’s disease participated in this study. Patients were divided into two groups: patients with visual hallucinations (VH group) and those without visual hallucinations (no-VH group). Unaided and corrected eyesight was evaluated in all patients, and if frequent use of prescription glasses or contact lenses was involved, eyesight using these lenses was also measured as the patient’s own best eyesight. If a patient did not use prescription glasses or contact lenses, the patient’s own best eyesight was defined as the unaided eyesight. Multivariate regression analysis demonstrated that agonist use and best eyesight were different after the backward elimination method. Visual hallucinations were closely related not to uncorrected eyesight or unaided eyesight but to the patient’s best eyesight. It is suggested that impaired visual acuity is a risk factor for visual hallucinations.

Key Words: Parkinson’s disease • visual hallucination • visual acuity • Charles-Bonnet syndrome

References

  • Saint-Cyr JA, Taylor AE, Lang AE. Neuropsychological and psychiatric side effects in the treatment of Parkinson’s disease. Neurology 1993;43(suppl 6): S47-S52.
  • Yamamoto M. Parkinson’s disease: Cognitive and psychiatric aspects. Tokyo: Chugai Igakusha, 2003.
  • Sanchez-Ramos JR, Ortoll R, Paulson GW. Visual hallucinations associated with Parkinson’s disease. Arch Neurol 1996;53:1265-1268.[Abstract]
  • Graham JM, Grunewald RA, Sagar HJ. Hallucinosis in idiopathic Parkinson’s disease. J Neurol Neurosurg Psychiatry 1997;63:434-440.[Abstract/Free Full Text]
  • Pappert EJ, Goetz CG, Niederman FG, et al. Hallucinations, sleep fragmentation, and altered dream phenomena in Parkinson’s disease. Mov Disord 1999;14:117-121.[CrossRef][Medline] [Order article via Infotrieve]
  • Factor SA, Molho ES, Podskalny GD, Brown D. Parkinson’s disease: drug-induced psychiatric states. Adv Neurol 1995;65:115-138.[Medline] [Order article via Infotrieve]
  • Harding AJ, Broe GA, Halliday GM. Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe. Brain 2002;125:391-403.[Abstract/Free Full Text]
  • Barnes J, David AS. Visual hallucinations in Parkinson’s disease: a review and phenomenological survey. J Neurol Neurosurg Psychiatry 2001;70:727-733.[Abstract/Free Full Text]
  • Matsui H, Udaka F, Oda M, et al. Two cases of Parkinson’s disease in which visual hallucinations disappeared after cataract surgery. No To Shinkei 2004;56:351-354.[Medline] [Order article via Infotrieve]
  • Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992;55:181-184.[Abstract]
  • Gilman S, Low PA, Quinn N, et al. Consensus statement on the diagnosis of multiple system atrophy. J Neurol Sci 1999;163:94-98.[CrossRef][Medline] [Order article via Infotrieve]
  • McKeith IG, Galasko D, Kosaka K, et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 1996;47:1113-1124.[Abstract/Free Full Text]
  • Friedman JH. The management of the levodopa psychoses. Clin Neuropharmacol 1991;14:283-295.[Medline] [Order article via Infotrieve]
  • Turner TH, Cookson JC, Wass JA, et al. Psychotic reactions during treatment of pituitary tumours with dopamine agonists. Br Med J 1984;289:1101-1103.
  • de Ajuriaguerra J. Etude psychopathologique des parkinsoniens. In: de Ajuriaguerra J, Gauthier G, eds. Monoamines, noyaux gris centraux et syndrome de Parkinson. Geneve, Masson, 1971: 327-355.
  • Rondot P, de Recondo J, Coignet A, Ziegler M. Mental disorders in Parkinson’s disease after treatment with L-DOPA. Adv Neurol 1984;40:259-269.[Medline] [Order article via Infotrieve]
  • Tanner CM, Vogel C, Goetz CG, Klawans HL. Hallucinations in Parkinson’s disease: a population study. Ann Neurol 1983;14:136.
  • Nagano O, Takauchi S, Nishitani H, Miyoshi K. Hallucinatory symptoms in Parkinson’s disease treatment with antiparkinsonian drugs. Clin Neurol 1986;26:464-470.
  • Shergill SS, Alker Z, Le Katona C. A preliminary investigation of laterality in Parkinson’s disease and susceptibility to psychosis. J Neurol Neurosurg Psychiatry 1998;65:610-611.[Free Full Text]
  • Barclay CL, Hildebrand K, Gray P, et al. Risk factors for the development of psychosis in Parkinson’s disease. Mov Disord 1997;12(suppl 1):108.
  • Meco G, Bonifati V, Cusimano G, et al. Hallucinations in Parkinson’s disease: neuropsychological study. Ital J Neurol Sci 1990;11:373-379.[CrossRef][Medline] [Order article via Infotrieve]
  • Aarsland D, Larsen JP, Cummings JL, Laake K. Prevalence and clinical correlates of psychotic symptoms in Parkinson’s disease. A community-based study. Arch Neurol 1999;56:595-601.[Abstract/Free Full Text]
  • Perry EK, Perry RH. Acetylcholine and hallucinations: disease-related compared to drug-induced alterations in human consciousness. Brain Cogn 1995;28:240-258.[CrossRef][Medline] [Order article via Infotrieve]
  • Stebbins GT, Goetz CG, Carrillo MC, et al. Altered cortical visual processing in PD with hallucinations: an fMRI study. Neurology 2004;63:1409-1416.[Abstract/Free Full Text]
  • Okada K, Suyama N, Oguro H, et al. Medication-induced hallucination and cerebral blood flow in Parkinson’s disease. J Neurol 1999;246:365-368.[CrossRef][Medline] [Order article via Infotrieve]
  • Nagano-Saito A, Washimi Y, Arahata Y, et al. Visual hallucination in Parkinson’s disease with FDG PET. Mov Disord 2004;19:801-806.[CrossRef][Medline] [Order article via Infotrieve]
  • Morsier G de. Le syndrome de Charles Bonnet: hallucinations visuelles des vieillards sans deficience mentale. Ann Med Psychol (Paris) 1967;125:677-702.
  • Cogan DG. Visual hallucinations as release phenomena. Graefe’s Arch Clin Exp Ophthalmol 1973;188:139-150.
  • White NJ. Complex visual hallucinations in partial blindness due to eye disease. Br J Psychiatry 1980;136:284-286.[Abstract/Free Full Text]
  • Berrios GE, Brook P. The Charles Bonnet syndrome and the problem of visual perceptual disorders in the elderly. Age Ageing 1982;11:17-23.[Abstract/Free Full Text]
  • Damas-Mora J, Skelton-Robinson M, Jenner FA. The Charles Bonnet syndrome in perspective. Psychol Med 1982;12:251-261.[Medline] [Order article via Infotrieve]
  • Teunisse RJ, Cruysberg JR, Hoefnagels WH, et al. Visual hallucinations in psychologically normal people: Charles Bonnet’s syndrome. Lancet 1996;347:794-797.[CrossRef][Medline] [Order article via Infotrieve]
  • Moskowitz C, Hamilton M, Klawans H. Levodopa-induced psychosis: a kindling phenomenon. Am J Psychiatry 1978;135:669-675.[Abstract/Free Full Text]
  • Inzelberg R, Kipervasser S, Korezyn AD. Auditory hallucinations in Parkinson’s disease. J Neurol Neurosurg Psychiatry 1998;64:533-535.[Abstract/Free Full Text]
  • Manford M, Andermann F. Complex visual hallucinations. Clinical and neurobiological insights. Brain 1998;121:1819-1840.[Abstract/Free Full Text]
  • Holroyd S, Sheldon-Keller A. A study of visual hallucinations in Alzheimer’s disease. J Am Geriatr Soc 1995;3:198-205.
  • McShane R, Gedling K, Reading M, et al. Prospective study of relations between cortical Lewy bodies, poor eyesight, and hallucinations in Alzheimer’s disease. J Neurol Neurosurg Psychiatry 1995;59:185-188.[Abstract]
  • Fiona M, Jane D, Ian M, Clive B. Association among visual hallucinations, visual acuity, and specific eye pathologies in Alzheimer’s disease: treatment implications. Am J Psychiatry 1999;156:1983-1985.[Abstract/Free Full Text]
  • Holroyd S, Currie L, Wooten GF. Prospective study of hallucinations and delusions in Parkinson’s disease. J Neurol Neurosurg Psychiatry 2001;70:734-738.[Abstract/Free Full Text]
  • Bodis-Wollner I. Visual deficits related to dopamine deficiency in experimental animals and Parkinson’s disease patients. Trends Neurosci 1990;13:296-302.[CrossRef][Medline] [Order article via Infotrieve]
  • Buttter T, Kuhn W, Muller T, et al. Distorted color discrimination in ‘de no vo’ parkinsonian patients. Neurology 1995;45:386-387.[Abstract]
  • Diederich NJ, Goetz CG, Raman R, et al. Poor visual discrimination and visual hallucinations in Parkinson’s disease. Clin Neuropharmacol 1998;21:289-295.[Medline] [Order article via Infotrieve]
  • Buttner T, Kuhn W, Muller T, et al. Visual hallucinations: the major clinical determinant of distorted chromatic contour perception in Parkinson’s disease. J Neural Transm 1996;103:1195-1204.[CrossRef]

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