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Serum Brain-Derived Neurotrophic Factor Is Associated With Cognitive Function in Healthy Older Adults

^* To whom correspondence should be addressed. E-mail: jgunstad{at}kent.edu.

	Abstract

Cognitive decline is common in older adults, even in the absence of significant medical or neurological conditions. Recent work implicates serum levels of brain-derived neurotrophic factor in age-related cognitive decline, though no study has directly examined this possibility. A total of 35 older adults without neurological history underwent fasting blood draw and completed a brief neuropsychological test battery during a single session. After adjusting for demographic and medical confounds, higher serum brain-derived neurotrophic factor levels were associated with better performance on the Mini-Mental State Examination (r = .36) and short form of the Boston Naming Test (r = .39). These findings extend work from Alzheimer disease and vascular dementia samples and indicate that higher brain-derived neurotrophic factor levels are associated with better neuropsychological function in healthy older adults. The exact mechanisms for this relationship are unknown and require further examination.

First published on May 23, 2008, doi:10.1177/0891988708316860

Journal of Geriatric Psychiatry and Neurology 2008;21:166.

A more recent version of this article appeared on September 1, 2008


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